BACKGROUND With the evolving complexity surrounding cancer care, interprofessional education through simulation must be examined as a novel pedagogy. OBJECTIVE To provide a systematic review by way of an evolutionary concept analysis of interprofessional oncology simulation to advance understanding of its antecedents, attributes, and consequences. DESIGN Rogerian evolutionary concept analysis method. DATA SOURCES A convenience sample of peer-reviewed publications were retrieved from MEDLINE, CINAHL and PsycINFO from 2002-2019. RESULTS Literature investigating interprofessional oncology simulation is growing. Findings (N=16 articles) revealed congruent antecedents, while attributes included: (1) realistic oncology care scenarios, (2) training in complex oncology care, and (3) oncology care communication. The conceptual consequences were identified as improved interprofessional team, trainee, and patient care outcomes. CONCLUSIONS Findings advance knowledge in the growing area of interprofessional oncology simulation by providing conceptual clarification for healthcare providers. As professional organizations continue to emphasize interprofessional educational methods, additional research is critical in furthering this area of knowledge development.